SCIENTIFIC/RESEARCH LABORATORY MANAGER

Scientific Research Laboratory Manager

Flow Cytometry Facility – Duke Human Vaccine Institute

OVERVIEW:

The DHVI Flow Cytometry Facility has been providing state-of-the-art flow-based analysis and cell sorting for over 25 years. The Facility currently has two BD Symphony S6 sorters, one BD FACSAriaIII sorter, one BD Symphony A5 analyzer, one BD LSRFortessa analyzer, one BD LSRII analyzer, and one Sartorius iQue3 Screener. The facility has three full-time staff members, supports 120+ principal investigators, provides comprehensive training for 24/7 independent use of analytical instruments, and sorts samples at Biosafety levels 1, 2 and 3, including CDC Select Agents.

The DHVI Flow Cytometry Facility has laboratories on Duke’s main campus and on Duke’s Research and Discovery@RTP campus. The Research Laboratory Manager position will be responsible for running the day-to-day operations of the facility, supervising facility personnel, operating cytometers as needed, and implementing innovative cytometry-based approaches in support of the scientific research activities of the Duke Human Vaccine Institute and collaborating entities.

RESPONSIBILITIES:

Administration (40%)

1. Collaborate with the DHVI Flow Cytometry Facility Director and the DHVI Administrative Manager for Finance to formulate short- and long-range goals for the scientific and financial operation of the Facility. Set priorities, assign responsibilities, and develop annual business plans and rates/fees for revenue neutrality. Prepare technical reports as needed reflecting volume of work, procedures utilized and study results. Coordinate the preparation of reports and analyses setting forth progress, adverse trends, and appropriate recommendations or conclusions. Work with the DHVI Flow Cytometry Facility Director on the preparation of equipment grants.
2. Manage the Flow Facility technical staff including recruitment and selection, performance management, and professional/skill development. Train, teach, and mentor staff as required.
3. Collaborate with DHVI leadership and Principal Investigators to bring new innovative flow-based applications and approaches to the Flow Facility.  Collaborate on preparing and completing research grants, contracts, scientific projects, and manuscripts. It is hoped that the Flow Facility Manager will become a full collaborative partner in all flow-based DHVI research.
4. Perform other duties as requested by the DHVI Flow Cytometry Facility Director, Shared Resources Scientific Director, COO, and Director.

Instrument Operation (40%)

1. Run Cell Sorters/Analyzers to meet the needs of facility end users, as directed by the Facility Director, Manager and DHVI leadership.
2. Ensure that all Flow Facility work is performed under DHVI-approved Standard Operating Procedures (SOPs) and provide day-to-day monitoring of safe work practices in the Facility to ensure full compliance with all safety regulations/SOPs.
3. Ensure all Flow Facility instruments are properly maintained and functioning at optimal performance levels. Develop and implement a real-time reporting system for instrument QA and service logs.  Ensure all data generated in the facility appropriately archived in a timely manner to ensure data integrity, provenance and long-term retrieval
4. Coordinate resource and staff scheduling to meet the needs of all facility users. Provide back-up operator coverage on all facility instruments as needed.

User Training (20%)

1. Provide training to new facility users for independent operation of an analysis flow cytometer, including instrument QC, experimental controls, sample acquisition, instrument shutdown, and data management.
2. Expand the existing Flow Facility training program (instrument operation) to include introductory and advanced flow techniques (e.g. sample preparation, panel development, and data analysis).

The successful candidate will be willing and able to:

• Work with hazardous biological agents handled at BSL2 and BSL3
• Comply with vaccination requirements when necessary
• Complete US Department of Justice screening for Select Agent registration
• Complete Select Agent registration at Tier 1
• Achieve external certification for independent work at BSL3

REQUIRED QUALIFICATIONS AT THIS LEVEL:

• Education/Training: Bachelor’s degree in a scientific discipline or in the health or physical sciences. Master’s degree preferred. Ph.D. highly preferred.
• Experience: Minimum of seven years of experience. Must have previous experience managing projects. Experience must include a minimum of three years in a supervisory/managerial role.

PREFERENCES:

• Experience operating BD FACS Aria and/or Symphony cytometers.
• Experience with complex polychromatic panel development and data analysis for surface and intracellular phenotyping for basic (mouse, non-human primate) and clinical studies (human).
• Experience in Biosafety Level 3 containment.

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