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RESEARCH SCIENTIST

Req ID:  1888
Date:  Aug 14, 2019
Location: 

Durham, NC, US, 27710

Personnel Area:  MEDICAL CENTER

School of Medicine:

 

Established in 1930, Duke University School of Medicine is the youngest of the nation’s top medical schools. Ranked tenth among its peers, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where traditional barriers are low, interdisciplinary collaboration is embraced, and great ideas accelerate translation of fundamental scientific discoveries to improve humanhealth locally and around the globe.

 

Comprised of 2,400 faculty physicians and researchers, the Duke University School of Medicine along with the Duke University School of Nursing and Duke University Health System create Duke Health. Duke Health is a world-class health care network. Founded in 1998 to provide efficient, responsive care, the health system offers a full network of health services and encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Private Diagnostic Clinic, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.

 

RESEARCH SCIENTIST, DHVI

The Duke Human Vaccine Institute (DHVI) continues to lead with cutting edge research to combat infectious diseases that impact global health.  The investigators at the DHVI conduct basic and translational research to develop novel vaccines, therapeutics and diagnostics for emerging pathogens, such as HIV-1, tuberculosis, influenza, malaria, cytomegalovirus, zika, chikungunya etc.

The Laboratory of Neonatal Viral Pathogen Immunity leads research in immunologic prevention of congenital and neonatal infections against neonatal viral pathogens, including HIV-1, CMV, Zika, and Rotavirus, identifying immune correlates of protection and testing vaccine strategies in preclinical models. We are recruiting a Research Scientist to oversee immunology aspects of the program and work closely with Dr. Permar to oversee the day-to-day research laboratory activities of technicians and students to meet the specific goals of the laboratory:

  • Develop and validate assays to measure T and B cell responses in mother and infant pairs and animal models against HIV, CMV, Rotavirus, and Zika
  • Design and implement studies of immune correlates of protection against vertical transmission of viral pathogens
  • Assist in the design and oversee studies to assess the role of maternal immune responses in protection against placental infection nonhuman primate model of congenital CMV infection
  • Oversee reagent development for measuring immune responses in required assays, such as antibody and protein production
  • Work with students and technicians to developing their experimental designs and troubleshoot their experiments
  • Quality control data generated by the laboratory for sharing with collaborators and publication

 

RESEARCH ACTIVITIES

Activities will include, but are not limited to, the following:

  • Design, develop and execute all required assays and model systems to meet the milestones of the research program:
    • Measure binding and functinal antibody responses
    • Identify and islate virus-specific B cells for monoclonal antibody characterization
    • Assess functinal T cell responses in human and animal models
  • Facilitate collaborations/interactions with the other scientific teams and collaborators/subcontractors working on this project.
  • Develop and implement standard operating procedures and lead in qualification and validation efforts for assays and procedures
  • Plan, organize, and conduct research projects with PI approval.
  • Research new products, tests, and methods and report on relative feasibility, quality, and benefits of new developments.
  • Collate, analyze, and quality control complex data sets.
  • Organize and present data sets to the PI and programmatic Leadership Teams.
  • Summarize completed protocols and studies; write scientific articles and manuscripts for publication and presentation.
  • Supervise and mentor lab staff, students, and fellows in the laboratory.
  • Monitor progress of research projects and coordinate with the Program Manager to stay on budget and schedule to meet the program milestones and deliverables. 

 

MINIMUM REQUIREMENTS

PhD or equivalent doctorate (e.g., Sc.D, M.D., D.M.V.), 5+ years of postdoctoral training or experience conducting scientific research in the field of immunology with multiple publications; Expertise in both cellular and molecular immunology techniques.

 

Duke University is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.

 

Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.

 

Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essential job functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.

 


Nearest Major Market: Durham
Nearest Secondary Market: Raleigh

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