RESEARCH SCHOLAR

Background- Dr. Bari lab is focused on microbial metabolomics and its cross talk with antitumor immune responses. Our work is translational evaluating the role of microbial metabolic pathways in mediating resistance to immunotherapy. We leverage patient samples as the cornerstone of our research and every endeavor in our lab is geared towards improving clinical outcomes for cancer patients. We are developing a metabolomics-based biomarker panel to predict responses to immunotherapy in solid cancers, thus advancing precision Oncology. Another area of interest is development of drugs to target microbial metabolic pathways that mediate resistance to immunotherapy, hence improving patients’ treatment response.

To achieve our goals, we are looking for a well experienced, enthusiastic and a diligent research scholar, with following details-

Occupational Summary

Understand, learn, perform and lead a variety of technical and scientific experiments involved in immune and microbial metabolomics research. An ideal candidate is one who has at least two years’ experience in lab research, preferably in immunology, metabolomics, microbiome or a combination of these. Proficiency with mice work is a requirement. The candidate should demonstrate scientific acumen, initiative and be able to brainstorm roadblocks.

Work Performed

Perform a variety of technical and scientific task involved in conducting physical, chemical or biological tests, experiments and determinations to obtain data in support of research-oriented activities, compile and document procedures and results. The scholar should also be able to supervise other research tech and less experienced staff in lab.

The Principal Investigator’s lab focusses on microbial metabolomics, hence following experience/skills are required in the ideal candidate-

• a) Mice studies including GF and SPF -all aspects including but not limited to cell line culture, expansion., injection to mice, tumor size, oral gavages, euthanasia, tumor and tissue collection, mice breeding, weaning etc. 
• b) Processing of human and mice samples- blood, tissue, fecal pellets.
• c)Single cell suspension prep, PCR, Western blot, ELISA, flow cytometry, cytotoxicity assay and other immunology experiments.
• d)Experiments may include fecal microbiota transfer to mice.
• e) Flow cytometry, PCR, Western blot, ELISA.
• Liquid chromatography mass spectrometry.
• f) Writing IUCUC and IRB protocols.
• f) Abstract and manuscript writing.
• h) Ordering supplies and managing the lab.
• i)Undergo necessary training to accomplish the tasks required.
• J) The candidate may have to consent patient, for sample collection protocol. Adequate training will be provided.
• J) Perform other related duties incidental to the work described herein.

More importantly, taking the initiative and being dedicated is vital.

The above statements describe the general nature and level of work being performed by individuals assigned to this classification. This is not intended to be an exhaustive list of all responsibilities and duties required of personnel so classified.

At least two years of full-time lab research experience is preferred.

Required Qualifications at this Level.

The intent of this job description is to provide a representative and level of the types of duties and responsibilities that will be required of positions given this title and shall not be construed as a declaration of the total of the specific duties and responsibilities of any particular position. Employees may be directed to perform job-related tasks other than those specifically presented in this description.

Duke University is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.

Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas-an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.

Essential Physical Job Functions

Certain jobs at Duke University and Duke University Health System may include essential job functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.

Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.

Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.

Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.