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RESEARCH ASSOCIATE, SENIOR - GLOBAL HEALTH DISCOVERY COLLABORATORY (GHDC0) ANTIBODY DYNAMICS

Work Arrangement: 
Requisition Number:  197144
Regular or Temporary:  Regular
Location: 

Durham, NC, US, 27710

Personnel Area:  MEDICAL CENTER
Date:  Nov 15, 2022
School of Medicine Established in 1930, Duke University School of Medicine is the youngest of the nation’s top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,500 faculty physicians and researchers, more than 1,300 students, and more than 6,000 staff, the Duke University School of Medicine along with the Duke University School of Nursing, Duke University Health System and the Private Diagnostic Clinic (PDC) comprise Duke Health. a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.

The Global Health Discovery Collaboratory (GHDC) Antibody Dynamics team at the Duke University Center for Human Systems Immunology (https://chsi.duke.edu/divisions/antibody-dynamics-and-immune-function) is seeking a detail-oriented scientist to fulfill a key role as Research Associate Sr. This position in the Biophysical Immunology group will play a leading role in planning, designing, and performing assays in two major areas of global health discovery research.

 

1. Epitope mapping, epitope binning and affinity landscape profiling of monoclonal antibodies, their derivatives engineered to aid developability and biologics candidates for therapeutics development targeted against diseases of global health importance.

 

2. Quantitating and assessing avidity of polyclonal antibodies elicited by pathogens or vaccination against global health pathogens including those that cause malaria and tuberculosis.

 

The study results generated by the person in this role will accelerate moving antibodies and other biologics candidates to clinic and will inform pre-clinical and human clinical trials for vaccines. The person in this role will also play a key role in assay development and standardization and in testing feasibility of novel methods.  This person must be very organized, possess excellent communication skills, have a high level of technical precision, be interested in assay development and optimization, enjoy working in a fast-paced lab environment with multiple priorities, and be able to work well as part of a team. 

 

Job functions include:

  • Design and perform high throughput surface plasmon resonance (SPR) and bio-layer interferometry (BLI) assays to identify lead monoclonal antibody and other biologics candidates for therapeutics development.
  • Perform comp lex and highly technical BLI and SPR assays in the laboratory to evaluate antibody dynamics in samples from clinical and preclinical vaccine trials. Carefully and accurately document assay conditions, results, and quality control findings and report them promptly to meet deadlines. 
  • Play a key role in the development and standardization of new assays, participating in discussions of next steps for follow up assays and in assay design.
  • Perform bio-layer interferometry (BLI), surface plasmon resonance (SPR), and other assays in the lab to develop new methods and protocols, optimize reagents, test various conditions, and determine feasibility of assays using novel antigens. 
  • Perform data analysis, model data using computational tools, make presentation of findings to collaborators/funders and write summary, qualification and validation documents.
  • Work with the laboratory and project managers to contribute to the overall effort for streamlining the workload, improve the efficiency of the Biophysical Immunology group, and contribute to the daily laboratory effort to adhere to Good Clinical Laboratory Practice (GCLP) guidelines. Lead writing new Standard Operating Procedures (SOP's) and editing/updating existing SOP's as needed.
  • Train new and junior personnel on various assays that use SPR, BLI and other biophysical techniques. Provide help in troubleshooting SPR and BLI assays.
  • Oversee to maintain laboratory and associated equipment in a clean, well-ordered, and functional manner.  Keep supplies on hand with a well-planned inventory and ordering system.   
  • Maintain laboratory notebook in an orderly fashion for tracking experiments and results. Provide written updates of work each week.

 

Education, Skills, & Experience Requirements

  • PhD in Biophysics, Biochemistry, Chemistry, Bioengineering or related field
  • Strong background in biophysical and biochemical laboratory techniques
  • Research experience in performing SPR/BLI assays.
  • Must be able to manage multiple and rapidly changing priorities and have the ability to quickly learn new skills
  • Must be detail-oriented and well organized with strong communication skills and the ability to work in a fast-paced interactive team environment.
  • Experience in using Mathematica and R-studio packages and working in GMP/GCLP compliant laboratories will be a plus.
  • Knowledge and interest or experience in humoral immunity will be a plus.

 

Minimum Qualifications
Education

See job description for education requirements.

 

Experience
See job description for requirements.

 

Interested applicants should submit an application at Duke Careers (https://careers.duke.edu/) and email resume to moses.sekaran@duke.edu

 

 

Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.

 

Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.

 

Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.

 


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