Share this Job


Requisition Number::  56401
Date:  Feb 19, 2021

Durham, NC, US, 27710

Personnel Area:  MEDICAL CENTER

School of Medicine:


Established in 1930, Duke University School of Medicine is the youngest of the nation’s top medical schools. Ranked tenth among its peers, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where traditional barriers are low, interdisciplinary collaboration is embraced, and great ideas accelerate translation of fundamental scientific discoveries to improve humanhealth locally and around the globe.


Comprised of 2,400 faculty physicians and researchers, the Duke University School of Medicine along with the Duke University School of Nursing and Duke University Health System create Duke Health. Duke Health is a world-class health care network. Founded in 1998 to provide efficient, responsive care, the health system offers a full network of health services and encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Private Diagnostic Clinic, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.


Job Description:

The Pe ndergast lab inthe Department of Pharmacology and Cancer Biology, Duke U niversity School ofMedicine is seeking to recruit a postdoctoral positio n to study the role oftyrosine kinase networks in the regulation of rege neration and repair followinginjury to the lung epithelium. Damage to th e lung epithelium by respiratoryinfections is associated with respirator y failure and induction of acuterespiratory distress syndrome which has an incidence of about 200,000 cases inthe United States each year and is associated with a high mortality rate. Currentlylittle is known regardi ng the identity of signaling networks that might beeffectively targeted to promote recovery from lung injury. We recently reportedthat genetic i nactivation of Abl1specifically in a subset of lung epithelial cells resulted in marked expansionof a progenitor cell population leadin g to alveolar regeneration followingbacterial pneumonia. Importantly, we found that treatment with ABL kinase specificinhibitors enhanced regene ration of the alveolar epithelium and promotedaccelerated recovery of mi ce following pneumonia. These and ongoing studies usingstate of the art technologies (single-cell RNA-seq, Spatial Transcriptomics,etc.) seek to develop new therapeutic strategies to treat lung injury induced bypatho gens and toxic agents (Khatri, et al 2019; Proc. Natl. Acad. Sci. US A 116: 1603-1612). We offer an inspiringintellectual, collaborative and multidisciplinary research environment tosupport your career goals and provide access to state-of-the-art facilities.


Candidates who are highly motivate d and share a vision of excellence and commitment to research witha recent Ph.D. in developmental biology, regenerative medicine, and/o r tumor biology using mouse models are preferred. Candidates sh ould have a strong inner drive, independence, and willingness to work in a highly interdisciplinary team. Candidates with demonstrated expertise in lung epithelial biology and interest on the study of regeneration an d repair pathways are encouraged to apply.

 Candidates must be leg ally authorized to work in the US. Applications will be reviewed until p ositions are filled. The positions are available immediately. 

How to Apply:

Please send C.V. and the names and e-m ail addresses of three references to:

Con tact Name:

Ann Marie Pendergast, Ph.D.

Anthony R. M eans Cancer Biology Professor

Vice Chair, Department of Pharmacolo gy and Cancer Biology
Director of Graduate Studies, Molecular Cancer Biology


Contact Email:< /p>



Minimum Qualifications


See job description for education requirements.


See job description for requirements.


Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.


Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.


Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.


Nearest Major Market: Durham
Nearest Secondary Market: Raleigh