POSTDOCTORAL ASSOCIATE

Work Arrangement:

Requisition Number: 251202

Regular or Temporary: Regular

Location:

Durham, NC, US, 27710

Personnel Area: MEDICAL CENTER

Date: Oct 24, 2024

School of Medicine Established in 1930, Duke University School of Medicine is the youngest of the nation's top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,500 faculty physicians and researchers, more than 1,300 students, and more than 6,000 staff, the Duke University School of Medicine along with the Duke University School of Nursing, Duke University Health System and the Private Diagnostic Clinic (PDC) comprise Duke Health. a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.

This position for a new PhD will carry out translational studies involving G protein-coupled receptor (GPCR) signaling in heart failure and cardiomyopathy. These will include investigating the role of GPCR kinase 2 and 5 (GRK2 and GRK5) with novel binding partners in human cardiac myocytes derived from pluripotent stem cells. These novel partners will include proteins known to be involved with human cardiomyopathy and recently found to interact with GRK5 via a proteomic screen. Involvement in these interactions in heart failure pathology will involve cell work and will transition to in vivo animal work in genetically engineered mouse models. Experiences with iPSC-derived myocytes and in vivo mouse studies a plus. Independent research projects and team work included in this lab environment.

Minimum Qualifications

Education

See job description for education requirements.

Experience

See job description for requirements.

Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.

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Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.