Work Arrangement: 
Requisition Number:  243890
Regular or Temporary:  Regular

Durham, NC, US, 27710

Personnel Area:  MEDICAL CENTER
Date:  May 3, 2024

This Position is Grant Funded

School of Medicine

Established in 1930, Duke University School of Medicine is the youngest of the nation's top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,600 faculty physicians and researchers, nearly 2,000 students, and more than 6,200 staff, the Duke University School of Medicine along with the Duke University School of Nursing, and Duke University Health System comprise Duke Health, a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Health Integrated Practice, Duke Primary Care, Duke Home Care and Hospice, Duke Health and Wellness, and multiple affiliations.

Postdoctoral Associate

Henderson Lab – Duke Human Vaccine Institute


The Duke Human Vaccine Institute (DHVI) performs basic and translationalresearch to fight against major infectious diseases. DHVI is seeking Postdoctoral Associates to join the fight against the HIV-1 virus.  The DHVI is an interdisciplinary, interdepartmental institute dedicated to the study of host-pathogen interactions that can be translated into biologics and vaccines. DHVI is composed of a team of highly interactive investigators that have expertise in mucosal and systemic immunology, virology, molecular and structural biology, computational biology, and animal medicine. 


We are seeking a motivated individual to join our team who is dedicated to studying the HIV-1 Envelope fusion protein with experience in computational and/or experimental structural biology involving protein design, molecular dynamics simulation, single particle cryo-electron microscopy, x-ray crystallography, or single-molecule FRET. The Postdoctoral Associate will work independently to develop and apply computational and experimental methods to study fusion protein dynamics to aid in developing an HIV-1 vaccine. The multi-disciplinary approach to vaccine development at DHVI will afford the Postdoctoral Associate exposure to many areas of vaccine research with a multitude of opportunities to apply both computational and experimental structural biology methods to efforts aimed at combating the HIV-1 pandemic. Under the guidance of the Principal Investigator, the candidate will be responsible for developing methodology, performing data analysis, designing, and executing experiments, presenting the results at internal and external meetings, and drafting scientific publications. These studies will have a major impact on vaccine development that will be translated to first-in-humans clinical trials. 


The Postdoctoral Associate will perform some or all of the following activities: 

  • Study the structure and dynamics of the HIV-1 Envelope on the surface of virus-like particles. 
  • Computational protein design of HIV-1 fusion protein conformation.
  • Molecular simulation of HIV-1 Envelope proteins to inform vaccine design. 
  • High-resolution structure determination via single particle cryo-electron microscopy and/or cryo-electron tomography to study HIV-1 fusion protein structure. 
  • Design, develop, and implement computational programs to assist with the performance of the above activities. 
  • Present scientific results at meetings and publish results in peer-reviewed journals. 
  • Training in bioethics, laboratory management, and scientific writing. 
  • Maintain accurate laboratory documentation of experiments, including raw experimental data and laboratory notebooks. 


The position requires a PhD in computational biology, bioinformatics, structural biology, biophysics, biochemistry, or a related discipline and a strong record of publications in peer-reviewed journals. The candidate is expected to have a strong background in computer programming and familiarity working in a high-performance computing environment. Ideal candidates will possess excellent oral and written communication skills with the ability to work in a highly collaborative team environment. 



Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.


Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.


Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.


Nearest Major Market: Durham
Nearest Secondary Market: Raleigh