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LAB RESEARCH ANALYST II

Requisition Number::  96489
Date:  Apr 10, 2021
Location: 

Durham, NC, US, 27710

Personnel Area:  MEDICAL CENTER

School of Medicine:

 

Established in 1930, Duke University School of Medicine is the youngest of the nation’s top medical schools. Ranked tenth among its peers, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where traditional barriers are low, interdisciplinary collaboration is embraced, and great ideas accelerate translation of fundamental scientific discoveries to improve humanhealth locally and around the globe.

 

Comprised of 2,400 faculty physicians and researchers, the Duke University School of Medicine along with the Duke University School of Nursing and Duke University Health System create Duke Health. Duke Health is a world-class health care network. Founded in 1998 to provide efficient, responsive care, the health system offers a full network of health services and encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Private Diagnostic Clinic, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.

 

Position Description:

Occupational Summary:

Seeking a self-starting scientist with good problem-solving skills and strengths in quantitative analysis, particularly by LC-MS/MS.  Job duties will be to work in a fast-paced, team-based environment to conduct a variety of complex and independent investigations addressing physical, chemical, and other research laboratory experiments to obtain and interpret data for research projects at Duke, specifically addressing metabolomics and proteomics in cancer, neurodegenerative diseases, and infectious diseases.  Scientific integrity, curiosity, and determination are key qualities of a successful candidate.

 

In particular, under the guidance of the Director or Assistant Director, the Lab Analyst II will conduct a variety of complex laboratory procedures and specialized laboratory techniques for the analysis of endogenous metabolites, drug molecules, peptides and proteins in the Proteomics and Metabolomics Core Facility for the School of Medicine.  Note that both SOP-driven and independent analyses will be required, and proven analytical thinking and problem-solving skills are critical.  The ability to effectively work in a multidisciplinary team environment and move easily from one task to another is essential.

 

Tasks may include:

1) 40% - Preparation of biological samples for metabolomic, proteomic, and pharmacokinetic analyses.

 

2) 40% - Quantification of metabolites using triple quadrupole mass spectrometry, and contribution to the development of new LC-MS/MS assays.  Validation of figures of merit for quantitative LC-MS/MS assay.

 

3) 10% - Protein identification and quantitation using nanoscale capillary liquid chromatography and analytical scale liquid chromatography coupled with either high resolution, accurate mass tandem mass spectrometers (LC/MS/MS) or triple quadrupole mass spectrometers operated in MRM mode.

 

4) 5% - Contribution to written reports and publications of results in collaboration with investigators inside and outside of Duke.  Review journals, abstracts and scientific literature to keep abreast of new developments and to obtain information regarding previous experiments to aid in the design and development of original procedures and techniques.

 

5) 5% - Presentation of their ongoing work at group meetings, and critical evaluation of new approaches for metabolomics and proteomics presented in the literature or by others.

 

Minimum Qualifications
Education

Work requires a bachelor's degree in botany, biology, zoology, psychology or other directly related scientific field.

 

Experience
Work requires four years of research experience. A related master's OR AN EQUIVALENT COMBINATION OF RELEVANT EDUCATION AND/OR EXPERIENCE degree may off set required years of experience on a 1:1 basis, e.g., a two year master's degree in lieu of two years of experience.

 

Experimental design/planning, sample preparation, LC/MS/MS sample analysis and results interpretation skills are essential.  Additional skills in statistics, bioinformatics, or programming are a plus.

 

 

Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.

 

Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.

 

Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.

 


Nearest Major Market: Durham
Nearest Secondary Market: Raleigh