Work Arrangement: 
Requisition Number:  228282
Regular or Temporary:  Regular

Durham, NC, US, 27710

Personnel Area:  MEDICAL CENTER
Date:  Apr 10, 2024

This Position is Grant Funded

School of Medicine Established in 1930, Duke University School of Medicine is the youngest of the nation's top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,500 faculty physicians and researchers, more than 1,300 students, and more than 6,000 staff, the Duke University School of Medicine along with the Duke University School of Nursing, Duke University Health System and the Private Diagnostic Clinic (PDC) comprise Duke Health. a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.

Lab Research Analyst I

Acharya Lab, Division of Structural Biology

Duke Human Vaccine Institute


We are seeking a qualified and talented Lab Research Analyst I to join our structural biology team. The primary overall responsibilities of the position will be to support protein expression and purification for structural studies, perform biophysical, biochemical and virological assays, and assist in the management of the lab.




  • Perform the expression of proteins in commonly used systems (E coli, insect, mammalian).
  • Perform purifications that involve typical methodologies (IEX, SEC) and may occasionally involve the generation of specialized media for affinity chromatography.
  • Independently write and contribute to scientific manuscripts.
  • Independently write and contribute to the development of new protocols.
  • Independently perform a variety of complex technical duties involved in conducting research laboratory assays, experiments and determinations to obtain data under standard operating procedure (SOP)-driven best practices; compile, analyze, and document primary data.
  • Train and guide junior staff on laboratory technique, safety, and standard practices. Major emphasis on cell culture.
  • Confer with Principal Investigator and laboratory leadership to review work assignments and develop plans for experiments; make modifications to existing laboratory procedures and techniques to meet the needs of particular studies as required.
  • Attend all required training.
  • Interface with virology laboratories to perform assays in BSL3 settings.
  • Manage and complete all assigned tasks/projects in accordance with standardized operating procedures and in full compliance with all safety protocols.
  • Assist in managing laboratory space by keeping a well-stocked inventory and maintaining equipment.
  • Maintain laboratory notebook and other documentation in an orderly and accurate fashion for tracking work progress, experiments, and results.
  • Manage biological and chemical hazards in the lab -- MSDS's, chemical inventories, waste disposal, autoclaving, etc. as required.
  • Provide a summary of written work updates and plans each week.
  • Perform other duties as assigned by the Principal Investigator and laboratory leadership.


Education, Skills, & Experience Requirements

  • Requires a Bachelor’s degree in scientific discipline, health or physical sciences or a related filed; Master’s degree is a plus.
  • Minimum two years of relevant research experience.
  • Experience working in a BSL-3 lab required.
  • Experience in protein expression and purification desired.
  • Ability to troubleshoot and resolve problems.


Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.


Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.


Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.


Nearest Major Market: Durham
Nearest Secondary Market: Raleigh