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Requisition Number::  78008
Date:  Apr 6, 2021

Durham, NC, US, 27710

Personnel Area:  MEDICAL CENTER

School of Medicine:


Established in 1930, Duke University School of Medicine is the youngest of the nation’s top medical schools. Ranked tenth among its peers, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where traditional barriers are low, interdisciplinary collaboration is embraced, and great ideas accelerate translation of fundamental scientific discoveries to improve humanhealth locally and around the globe.


Comprised of 2,400 faculty physicians and researchers, the Duke University School of Medicine along with the Duke University School of Nursing and Duke University Health System create Duke Health. Duke Health is a world-class health care network. Founded in 1998 to provide efficient, responsive care, the health system offers a full network of health services and encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Private Diagnostic Clinic, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.


Occupational Summary

  • Prepare biologic samples, including plasma, serum, urine, lysates of cultured cells, homogenates of tissues, and feces from human subjects, and from laboratory animals, for: (1) targeted mass spectrometry (MS) analysis of aminoacids, acylcarnitines, organic acids, and other metabolites via gas chromatography(GC) / MS and liquid chromatography (LC) / MS; (2) un-targeted, exploratory metabolomics via GC / MS and UHPLC / Q-tof MS; and (3) measurement of metabolic flux, via all of those technologies.
  • Independently operate LC-MS / MS (Waters, Sciex), UHPLC / QToF MS (Agilent), and GC / MS(Thermo, Agilent) instruments.
  • Perform analyses of various biologic samples using established procedures and be able to modify them, as needed.
  • Develop new LC-MS  / MS methods for the targeted analysis of small molecules.
  • Process the data using such software packages as TargetLynx, NeoLynx, MassHunter,MassProfiler, Analyst, and Xcalibur.
  • Perform basic statistical analysis and review the data to ensure accuracy and quality control.
  • Troubleshoot and perform instrument maintenance such as cleaning the ion sources, injectors, and inlets, ballasting the pumps, tuning, and replacing capillaries and columns.
  •  Interact with customers to define their needs.
  • Actively participate in academic and industrial collaborations, developing plans for delivery of projects, and discussing interpretation of results.
  • Communicate with service engineers regarding any instrument issues and preventive maintenance.
  • Review journals, abstracts, and scientific literature to keep abreast of nondevelopments to obtain information regarding previous experiments to aid in the design and development of original procedures and techniques.
  • Maintain sufficient inventory of critical reagents and consumable supplies for performance of duties.
  • Prepare and keep inventories of reagents and solutions.
  • Perform other related duties, as assigned by the supervisor.


Minimum Qualifications

Work requires a bachelor's degree in botany, biology, zoology, psychology or other directly related scientific field.


Work requires two years of research experience. A related master's OR AN EQUIVALENT COMBINATION OF RELEVANT EDUCATION AND/OR EXPERIENCE degree may offset required years of experience on a 1:1 basis, e.g., a two year master's degree in lieu of two years of experience.


Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.


Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.


Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.


Nearest Major Market: Durham
Nearest Secondary Market: Raleigh